Malegra DXT Plus is marketed as a combination medicine for men experiencing erectile dysfunction (ED) and premature ejaculation (PE). The exact ingredients and strengths can vary depending on the manufacturer and market, so checking the package or prescription is important. These combination products commonly contain sildenafil, which improves blood flow to the penis during sexual stimulation, together with duloxetine, an SNRI that may help delay ejaculation. Because the two medicines work differently, the combination is intended to address both erection difficulties and premature ejaculation.